Tag Archive | Cholesterol

A study on soy-based food supplements

A study on soy-based food supplements as medical nutriceutical therapy in reversing lipid abnormalities

was conducted by:

Sison Jorge, MD, Aragon Jimmy, MD, Maliwat Raquel  MD, Yape Myrna, MD

Medical Center Manila, Makati Medical Center, Medical City Philippines


Cardiovascular diseases rank number one in causing death globally.

Lipid abnormalities like high cholesterol, triglycerides, LDL (“bad cholesterol”) and HDL (“good cholesterol”) are major risk factors for cardiovascular disease.

Soy and fibers have been proven to improve lipid abnormalities and therefore, benefit health.


To determine the efficacy and safety of soy based oral food supplements Reliv Now and Fibrestore in the management of lipid abnormalities.

 Study Design

60-day multi-center, prospective, randomized, double-blind, placebo-controlled trial on soy-based food supplements.


Adults (_>18 years old) with lipid abnormalities, which may be any of the following; high cholesterol, tryglicerides, LDL.


Decrease in average cholesterol level after 60 days was seen only in Reliv Now and Fibrestore.

Decrease in LDL level after 60 days was seen only in Reliv Now & Fibrestore.

Triglyceride level was reduced by FibRestore after 60 days.



had greater reduction in fasting

plasma glucose

level after 60 days

Relìv Now


& FibRestore® showed reduction in

blood uric acid

levels after 60 days

Changes in average weight after 60 days

Relìv Now


& FibRestore® showed greater


in cholesterol and triglycerides among



Relìv Now


& FibRestore® showed greater reduction


cholesterol among overweight subjects


Relìv Now

® and FibRestore®:

Reduced average cholesterol by 14%

Reduced average LDL by 18% and 8%, respectively

Reduced average triglycerides by 1.2% and 12.4%,


Reduced average uric acid by 10.4% and 16.7%,


Greater reduction in cholesterol and triglycerides


diabetic or overweight individuals


This study proved that Relìv

® Now and


® are effective food supplements in

correcting lipid abnormalities and hence, may help in lowering the risk for cardiovascular disease.



CardioSentials gives you a nutritional solution for total heart health. The revolutionary formula has been clinically shown to improve cholesterol, triglycerides and blood glucose levels. Phytosterols moderate cholesterol levels; policosanol improves coronary blood flow; and an array of potent antioxidants protect arterial walls. CardioSentials; take it to heart.

Plant Sterol Concentrate (Phytosterols) 1500 mg

are steroid compounds similar to cholesterol which occur in plants. Free phytosterols extracted from oils are insoluble in water, relatively insoluble in oil, and soluble in alcohols. Phytosterol enriched foods and dietary supplements have been marketed for decades. Despite well documented cholesterol lowering effect no evidence of any beneficial effect on CVD or overall mortality exists and a meta-analysis published in 2012 suggests that there is no effect.

The ability of phytosterols to reduce cholesterol levels was first demonstrated in humans in 1953. They were subsequently marketed as a pharmaceutical under the name Cytellin as a treatment for elevated cholesterol from 1954-1982.

Phytosterols may inhibit lung, stomach, ovarian and breast cancers. It increases antioxidant enzyme activity.

Phytosterol have a long history of safe use dating back to Cytellin, the pharmaceutical preparation of phytosterols marketed in the U.S from 1954-1982. Phytosterol esters have generally recognized as safe (GRAS) status in the US. Phytosterol containing functional foods were subject to post-launch monitoring after being introduced to the E.U market in 2000 and no unpredicted side-effects were reported.

Psyllium Husk (Plantago ovata) 100 mg

is the common name used for several members of the plant genus Plantago whose seeds are used commercially for the production of mucilage.

Psyllium is mainly used as a dietary fiber, which is not absorbed by the small intestine. The purely mechanical action of psyllium mucilage absorbs excess water while stimulating normal bowel elimination. Although its main use has been as a laxative, it is more appropriately termed a true dietary fiber and as such can help reduce the symptoms of both constipation and mild diarrhea. The laxative properties of psyllium are attributed to the fiber absorbing water and subsequently softening the stool. At the same time, this added bulk causes the stool to be better formed, which can reduce symptoms of diarrhea.

Beta Glucan 486 mg

are polysaccharides of D-glucose monomers linked by β-glycosidic bonds. β-glucans are a diverse group of molecules that can vary with respect to molecular mass, solubility, viscosity, and three-dimensional configuration. They occur most commonly as cellulose in plants, the bran of cereal grains, the cell wall of baker’s yeast, certain fungi, mushrooms and bacteria. Some forms of beta glucans are useful in human nutrition as texturing agents and as soluble fiber supplements, but can be problematic in the process of brewing.

β-glucans are known as “biological response modifiers” because of their ability to activate the immune system.

Several health claims requests were submitted to the EFSA NDA Panel (Dietetic Products, Nutrition and Allergies), related to the role of β-glucans in “maintenance of normal blood cholesterol concentrations and maintenance or achievement of a normal body weight“. In July 2009, the Scientific Committee issued the following statements:[6]

  • On the basis of the data available, the Panel concludes that a cause and effect relationship has been established between the consumption of beta-glucans and the reduction of blood cholesterol concentrations.
  • The following wording reflects the scientific evidence: “Regular consumption of beta-glucans contributes to maintenance of normal blood cholesterol concentrations“. In order to bear the claim, foods should provide at least 3 g/d of beta-glucans from oats, oat bran, barley, barley bran, or from mixtures of non-processed or minimally processed beta-glucans in one or more servings. The target population is adults with normal or mildly elevated blood cholesterol concentrations.
  • On the basis of the data available the Panel concludes that a cause and effect relationship has not been established between the consumption of beta-glucans and the maintenance or achievement of a normal body weight.

Pantethine 360 mg

is a dimeric form of pantothenic acid (vitamin B5). Pantethine is available as a dietary supplement because of evidence of its health benefits. In multiple clinical trials of patients with elevated cholesterol and triglycerides, total and LDL cholesterol were decreased by 12%, triglycerides decreased by 18%, and HDL cholesterol was increased by 9%.

Gugulipid 2.5% (Commiphora mukul) 350 mg

Gugulipid is a standardized extract of the gum resin from Commiphora mukul (2.5% Guggulsterones Z&E), and has been used to help support the maintenance of healthy levels of cholesterol and blood serum lipids.

Potassium D-Glucarate 200 mg

Potassium d-glucarate is a natural compound found in the body that helps cells to detoxify by enhancing the cell’s ability to absorb oxygen and nutrients. It also has been shown to help enzymes activate nerve transmission, and maintain a healthy cardiovascular system.

Magnesium Salvianolate 60% 150 mg

Magnesium is an essential mineral for human nutrition. It is necessary in the formation of bones and teeth and assists with absorption of calcium and potassium. It helps muscles contract and relax, while producing and transporting energy within the body. According to a study published in the journal, Neuron, the nutritional supplement magnesium can help boost an individual’s brain power by enhancing short and long-term memory as well as the ability to learn.

(Dansheng (Salvia miltiorrhiza))

also known as red sage, Chinese sage, tan shen, or danshen, is a perennial plant in the genus Salvia, highly valued for its roots in traditional Chinese medicine. Native to China and Japan, it grows at 90 to 1,200 m (300 to 3,900 ft) elevation, preferring grassy places in forests, hillsides, and along stream banks. The specific epithet miltiorrhiza means “red juice extracted from a root”.

Artichoke Extract (Cynara scolymus) 100 mg

The globe artichoke (Cynara cardunculus var. scolymus) is a perennial thistle of the genus Cynara originating in Southern Europe around the Mediterranean. An aid to digestion, strengthening of the liver function and gall bladder function, and raising of the HDL/LDL ratio. This reduces cholesterol levels, which diminishes the risk for arteriosclerosis and coronary heart disease,reduce cholesterol by inhibiting HMG-CoA reductase and having a hypolipidemic influence, lowering blood cholesterol. Artichoke leaf extract has proved helpful for patients with functional dyspepsia, and may ameliorate symptoms of IBS.

Optiberry® 100 mg

Derived from a unique blend of wild blueberry, strawberry, cranberry, wild bilberry, elderberry and raspberry extracts, OptiBerry® contains standardized levels of anthocyanins formulated and tested to supply whole body antioxidant support.

Coenzyme Q 10 50 mg

also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10 /ˌkoʊ ˌkjuː ˈtɛn/, CoQ, Q10, or Q, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenylchemical subunits in its tail.

This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver and kidney—have the highest CoQ10 concentrations.There are three redox states of coenzyme Q10: fully oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol). The capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it to perform its functions in the electron transport chain and as an antioxidant respectively.

Protykin® RSV-5000 25 mg (Polygonum cuspidatum extract)

is a large, herbaceous perennial plant, native to eastern Asia in Japan, China and Korea. In North America and Europe the species is very successful and has been classified as an invasive species in several countries. Methanol extracts of the roots of Polygonum cuspidatum (Polygonaceae), traditionally used in Korea to maintain oral health, were shown to reduce the viability of Streptococcus mutans and Streptococcus sobrinus as well as inhibit sucrose-dependent adherence, water-insoluble glucan formation, glycolytic acid production and acid tolerance. The authors suggested that inhibitory effects may be mediated by the presence of alkaloids, phenolics, sterols, and terpenes in the extract. Both Japanese knotweed and giant knotweed are important concentrated sources of resveratrol and its glucoside piceid, replacing grape byproducts. Many large supplement sources of resveratrol now use Japanese knotweed and use its scientific name in the supplement labels. The plant is useful because of its year-round growth and robustness in different climates.

Policosanol 20 mg (Saccharum officinarium extract)

Policosanol consists of numerous long-chained, fatty alcohols extracted from the plant, Saccharum officinarum, (sugar cane) and beeswax. The predominant alcohol in policosanol, octacosanol, has been previously shown to lower total cholesterol levels and LDL levels

Chromium 10 mcg (ChromeMate® brand of Niacin bound chromium)

ChromeMate® contains a unique patented niacin-bound chromium complex.  Chromium is an essential trace mineral that works to support healthy blood glucose levels already within a normal range and plays an important role in the proper utilization of protein, fats and carbohydrates.**  Independent studies show that ChromeMate® provides greater biological activity than other chromium supplements.

Proven Effective: In a double-blind, placebo-controlled clinical trial, participants taking CardioSentials significantly reduced total cholesterol, LDL (bad) cholesterol and triglycerides, as well as increased HDL (good) cholesterol and lowered blood glucose levels.

*These statements has not been evaluated by the Food and Drug Administration. This product is not intended to cure, mitigate, treat or prevent any disease.