Tag Archive | Heart

A study on soy-based food supplements

A study on soy-based food supplements as medical nutriceutical therapy in reversing lipid abnormalities

was conducted by:

Sison Jorge, MD, Aragon Jimmy, MD, Maliwat Raquel  MD, Yape Myrna, MD

Medical Center Manila, Makati Medical Center, Medical City Philippines

Introduction

Cardiovascular diseases rank number one in causing death globally.

Lipid abnormalities like high cholesterol, triglycerides, LDL (“bad cholesterol”) and HDL (“good cholesterol”) are major risk factors for cardiovascular disease.

Soy and fibers have been proven to improve lipid abnormalities and therefore, benefit health.

 Aim

To determine the efficacy and safety of soy based oral food supplements Reliv Now and Fibrestore in the management of lipid abnormalities.

 Study Design

60-day multi-center, prospective, randomized, double-blind, placebo-controlled trial on soy-based food supplements.

Inclusion

Adults (_>18 years old) with lipid abnormalities, which may be any of the following; high cholesterol, tryglicerides, LDL.

Results

Decrease in average cholesterol level after 60 days was seen only in Reliv Now and Fibrestore.

Decrease in LDL level after 60 days was seen only in Reliv Now & Fibrestore.

Triglyceride level was reduced by FibRestore after 60 days.

FibRestore

®

had greater reduction in fasting

plasma glucose

level after 60 days

Relìv Now

®

& FibRestore® showed reduction in

blood uric acid

levels after 60 days

Changes in average weight after 60 days

Relìv Now

®

& FibRestore® showed greater

reduction

in cholesterol and triglycerides among

diabetic

subjects

Relìv Now

®

& FibRestore® showed greater reduction

in

cholesterol among overweight subjects

SUMMARY

Relìv Now

® and FibRestore®:

Reduced average cholesterol by 14%

Reduced average LDL by 18% and 8%, respectively

Reduced average triglycerides by 1.2% and 12.4%,

respectively

Reduced average uric acid by 10.4% and 16.7%,

respectively

Greater reduction in cholesterol and triglycerides

among

diabetic or overweight individuals

CONCLUSION

This study proved that Relìv

® Now and

FibRestore

® are effective food supplements in

correcting lipid abnormalities and hence, may help in lowering the risk for cardiovascular disease.

CardioSentials®

CardioSentials gives you a nutritional solution for total heart health. The revolutionary formula has been clinically shown to improve cholesterol, triglycerides and blood glucose levels. Phytosterols moderate cholesterol levels; policosanol improves coronary blood flow; and an array of potent antioxidants protect arterial walls. CardioSentials; take it to heart.

Plant Sterol Concentrate (Phytosterols) 1500 mg

are steroid compounds similar to cholesterol which occur in plants. Free phytosterols extracted from oils are insoluble in water, relatively insoluble in oil, and soluble in alcohols. Phytosterol enriched foods and dietary supplements have been marketed for decades. Despite well documented cholesterol lowering effect no evidence of any beneficial effect on CVD or overall mortality exists and a meta-analysis published in 2012 suggests that there is no effect.

The ability of phytosterols to reduce cholesterol levels was first demonstrated in humans in 1953. They were subsequently marketed as a pharmaceutical under the name Cytellin as a treatment for elevated cholesterol from 1954-1982.

Phytosterols may inhibit lung, stomach, ovarian and breast cancers. It increases antioxidant enzyme activity.

Phytosterol have a long history of safe use dating back to Cytellin, the pharmaceutical preparation of phytosterols marketed in the U.S from 1954-1982. Phytosterol esters have generally recognized as safe (GRAS) status in the US. Phytosterol containing functional foods were subject to post-launch monitoring after being introduced to the E.U market in 2000 and no unpredicted side-effects were reported.

Psyllium Husk (Plantago ovata) 100 mg

is the common name used for several members of the plant genus Plantago whose seeds are used commercially for the production of mucilage.

Psyllium is mainly used as a dietary fiber, which is not absorbed by the small intestine. The purely mechanical action of psyllium mucilage absorbs excess water while stimulating normal bowel elimination. Although its main use has been as a laxative, it is more appropriately termed a true dietary fiber and as such can help reduce the symptoms of both constipation and mild diarrhea. The laxative properties of psyllium are attributed to the fiber absorbing water and subsequently softening the stool. At the same time, this added bulk causes the stool to be better formed, which can reduce symptoms of diarrhea.

Beta Glucan 486 mg

are polysaccharides of D-glucose monomers linked by β-glycosidic bonds. β-glucans are a diverse group of molecules that can vary with respect to molecular mass, solubility, viscosity, and three-dimensional configuration. They occur most commonly as cellulose in plants, the bran of cereal grains, the cell wall of baker’s yeast, certain fungi, mushrooms and bacteria. Some forms of beta glucans are useful in human nutrition as texturing agents and as soluble fiber supplements, but can be problematic in the process of brewing.

β-glucans are known as “biological response modifiers” because of their ability to activate the immune system.

Several health claims requests were submitted to the EFSA NDA Panel (Dietetic Products, Nutrition and Allergies), related to the role of β-glucans in “maintenance of normal blood cholesterol concentrations and maintenance or achievement of a normal body weight“. In July 2009, the Scientific Committee issued the following statements:[6]

  • On the basis of the data available, the Panel concludes that a cause and effect relationship has been established between the consumption of beta-glucans and the reduction of blood cholesterol concentrations.
  • The following wording reflects the scientific evidence: “Regular consumption of beta-glucans contributes to maintenance of normal blood cholesterol concentrations“. In order to bear the claim, foods should provide at least 3 g/d of beta-glucans from oats, oat bran, barley, barley bran, or from mixtures of non-processed or minimally processed beta-glucans in one or more servings. The target population is adults with normal or mildly elevated blood cholesterol concentrations.
  • On the basis of the data available the Panel concludes that a cause and effect relationship has not been established between the consumption of beta-glucans and the maintenance or achievement of a normal body weight.

Pantethine 360 mg

is a dimeric form of pantothenic acid (vitamin B5). Pantethine is available as a dietary supplement because of evidence of its health benefits. In multiple clinical trials of patients with elevated cholesterol and triglycerides, total and LDL cholesterol were decreased by 12%, triglycerides decreased by 18%, and HDL cholesterol was increased by 9%.

Gugulipid 2.5% (Commiphora mukul) 350 mg

Gugulipid is a standardized extract of the gum resin from Commiphora mukul (2.5% Guggulsterones Z&E), and has been used to help support the maintenance of healthy levels of cholesterol and blood serum lipids.

Potassium D-Glucarate 200 mg

Potassium d-glucarate is a natural compound found in the body that helps cells to detoxify by enhancing the cell’s ability to absorb oxygen and nutrients. It also has been shown to help enzymes activate nerve transmission, and maintain a healthy cardiovascular system.

Magnesium Salvianolate 60% 150 mg

Magnesium is an essential mineral for human nutrition. It is necessary in the formation of bones and teeth and assists with absorption of calcium and potassium. It helps muscles contract and relax, while producing and transporting energy within the body. According to a study published in the journal, Neuron, the nutritional supplement magnesium can help boost an individual’s brain power by enhancing short and long-term memory as well as the ability to learn.

(Dansheng (Salvia miltiorrhiza))

also known as red sage, Chinese sage, tan shen, or danshen, is a perennial plant in the genus Salvia, highly valued for its roots in traditional Chinese medicine. Native to China and Japan, it grows at 90 to 1,200 m (300 to 3,900 ft) elevation, preferring grassy places in forests, hillsides, and along stream banks. The specific epithet miltiorrhiza means “red juice extracted from a root”.

Artichoke Extract (Cynara scolymus) 100 mg

The globe artichoke (Cynara cardunculus var. scolymus) is a perennial thistle of the genus Cynara originating in Southern Europe around the Mediterranean. An aid to digestion, strengthening of the liver function and gall bladder function, and raising of the HDL/LDL ratio. This reduces cholesterol levels, which diminishes the risk for arteriosclerosis and coronary heart disease,reduce cholesterol by inhibiting HMG-CoA reductase and having a hypolipidemic influence, lowering blood cholesterol. Artichoke leaf extract has proved helpful for patients with functional dyspepsia, and may ameliorate symptoms of IBS.

Optiberry® 100 mg

Derived from a unique blend of wild blueberry, strawberry, cranberry, wild bilberry, elderberry and raspberry extracts, OptiBerry® contains standardized levels of anthocyanins formulated and tested to supply whole body antioxidant support.

Coenzyme Q 10 50 mg

also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10 /ˌkoʊ ˌkjuː ˈtɛn/, CoQ, Q10, or Q, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenylchemical subunits in its tail.

This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver and kidney—have the highest CoQ10 concentrations.There are three redox states of coenzyme Q10: fully oxidized (ubiquinone), semiquinone (ubisemiquinone), and fully reduced (ubiquinol). The capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it to perform its functions in the electron transport chain and as an antioxidant respectively.

Protykin® RSV-5000 25 mg (Polygonum cuspidatum extract)

is a large, herbaceous perennial plant, native to eastern Asia in Japan, China and Korea. In North America and Europe the species is very successful and has been classified as an invasive species in several countries. Methanol extracts of the roots of Polygonum cuspidatum (Polygonaceae), traditionally used in Korea to maintain oral health, were shown to reduce the viability of Streptococcus mutans and Streptococcus sobrinus as well as inhibit sucrose-dependent adherence, water-insoluble glucan formation, glycolytic acid production and acid tolerance. The authors suggested that inhibitory effects may be mediated by the presence of alkaloids, phenolics, sterols, and terpenes in the extract. Both Japanese knotweed and giant knotweed are important concentrated sources of resveratrol and its glucoside piceid, replacing grape byproducts. Many large supplement sources of resveratrol now use Japanese knotweed and use its scientific name in the supplement labels. The plant is useful because of its year-round growth and robustness in different climates.

Policosanol 20 mg (Saccharum officinarium extract)

Policosanol consists of numerous long-chained, fatty alcohols extracted from the plant, Saccharum officinarum, (sugar cane) and beeswax. The predominant alcohol in policosanol, octacosanol, has been previously shown to lower total cholesterol levels and LDL levels

Chromium 10 mcg (ChromeMate® brand of Niacin bound chromium)

ChromeMate® contains a unique patented niacin-bound chromium complex.  Chromium is an essential trace mineral that works to support healthy blood glucose levels already within a normal range and plays an important role in the proper utilization of protein, fats and carbohydrates.**  Independent studies show that ChromeMate® provides greater biological activity than other chromium supplements.

Proven Effective: In a double-blind, placebo-controlled clinical trial, participants taking CardioSentials significantly reduced total cholesterol, LDL (bad) cholesterol and triglycerides, as well as increased HDL (good) cholesterol and lowered blood glucose levels.

*These statements has not been evaluated by the Food and Drug Administration. This product is not intended to cure, mitigate, treat or prevent any disease.

Whats in Pro Vantage

What is in Pro Vantage and is it safe? This is what I will be looking at in this blog. I am searching the ingredients list on the package. First on the list is Tonalin(conjugated linoleic acid{CLA})which is made from safflower oil. Next is Phosphatidylserine which is a phospholipid component, usually kept on the inner-leaflet (the cytosolic side) of cell membranes  an enzyme called flippase. Third is Creatine Monohydrate is a nitrogenous organic acid that occurs naturally in vertebrates. Extensive research over the last decade has shown that oral creatine supplementation at a rate of 5 to 20 grams per day appears to be very safe. Fourth on the list is Medium Chain Triglycerides. Some studies have shown that MCTs can help in the process of excess calorie burning, and thus weight loss. Next is Bioperine® (Piper nigrum) a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). Following we find Extract of grape seed (Vitis vinifera) There may be health benefits from the oil itself. Next we see  Alpha-Lipoic Acid an organosulfur compound derived from octanoic acid.  Then there is  Coenzyme Q 10  which helps to maintain a healthy cardiovascular system and more. Finally L-Carnitine is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy.

First we will take a look at Tonalin® (Conjugated linoleic acid {CLA})

Tonalin® Brand CLA is made from Safflower Oil.  Using Tonalin CLA (Conjugated Linoleic Acid) is great for weight loss, and can help if you have Diabetes, Cancer, and even  Atherosclerosis.  Tonalin® €LA is a safe, scientifically proven, effective nutritional supplement that contains no stimulants of any kind. However There are concerns that  CLA supplements by extremely overweight people may tend to cause or to aggravate insulin resistance, which may increase their risk of developing diabetes.  The general consensus is that the use of this supplement should be carefully examined if the person using the supplement is greatly overweight.

Phosphatidylserine– 

 (abbreviated Ptd-L-Ser or PS) is a phospholipid component of cell membranes. When a cell undergoes apoptosis, phosphatidylserine is no longer restricted to the cytosolic part of the membrane, but becomes exposed on the surface of the cell. Possible Health benefits: Memory and cognition-Commercially available products are made from soybeans. FDA did, however give “qualified health claim” status to phosphatidylserine, stating that, “Consumption of phosphatidylserine may reduce the risk of dementia in the elderly” and “Consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly.”  Sports nutrition- Soy-PS, in a dose dependent manner (400 mg), has been reported to be an effective supplement for combating exercise-induced stress by blunting the exercise-induced increase in cortisol levels.PS supplementation promotes a desirable hormonal balance for athletes and might attenuate the physiological deterioration that accompanies overtraining and/or overstretching. In recent studies, PS has been shown to enhance mood in a cohort of young people during mental stress and to improve accuracy during tee-off by increasing the stress resistance of golfers.   Attention-deficit hyperactivity disorder-First pilot studies indicate that PS supplementation might be beneficial for children with attention-deficit hyperactivity disorder.  Safety-  Soy-derived PS is Generally Recognized As Safe (GRAS) and is a safe nutritional supplement for older persons if taken up to a dosage of 200 mg three times daily. Phosphatidylserine has been shown to reduce specific immune response in mice.

Phosphatidylcholine

They are a major component of biological membranes and can be easily obtained from a variety of readily available sources such as egg yolk or soy beans from which they are mechanically extracted or chemically extracted using hexane. They are also a member of the lecithin group of yellow-brownish fatty substances occurring in animal and plant tissues.

Possible health benefits

Senescence:Phosphatidylcholine is a vital substance that is in every cell in the human body. Thus some researchers have used mutant mouse models with severe oxidative damage as a model of “accelerated aging” to investigate the possible role of phosphatidylcholine supplementation as a way of slowing down aging-related processes.  and improving brain functioning and memory capacity in dementia.However, a systematic review of clinical trials in humans found that lecithin or phosphatidylcholine supplementation does not benefit patients with dementia.

Liver repair:Recent studies point to the many potential benefits of phosphatidylcholine for liver repair. One study shows phosphatidylcholine’s healing effect with hepatitis A, hepatitis B, and hepatitis C. Phosphatidylcholine administration for chronic, active hepatitis resulted in significant reduction of disease activity in mice.

Lipolysis: Some organizations promote the use of injected phosphatidylcholine, otherwise known as injection lipolysis, claiming the procedure can break down fat cells, and thus serve as an alternative to liposuction. It is important to note that while the procedure cites early experiments that showed lipolysis in cases of fat emboli, no peer-reviewed studies have shown any amount of lipolysis even remotely comparable to liposuction.

Ulcerative colitis: Phase IIa/b clinical trials performed at the Heidelberg University Hospital have shown that delayed release phosphatidylcholine is an anti-inflammatory, and secondly, is a surface hydrophobicity increasing compound with promising therapeutic potential in the treatment of inflammatory bowel disease.

In addition to the increased caloric burden of a diet rich in fats like phosphatidylcholine, a recent report has linked the microbial catabolites of phosphatidylcholine with increased atherosclerosis through the production of choline, trimethylamine oxide, and betaine. However, the validity of this study is disputed because the form of choline used was contaminated with trimethylamine oxide (TMAO). A 1999 study by other authors who studied 46 different foods did not find choline-rich foods to cause TMAO production.

Creatine Monohydrate  is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle. Creatine supplements are used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass. While there was once some concern that creatine supplementation could affect hydration status and heat tolerance and lead to muscle cramping and diarrhea, recent studies have shown these concerns to be unfounded.

Extensive research over the last decade has shown that oral creatine supplementation at a rate of 5 to 20 grams per day appears to be very safe and largely devoid of adverse side-effects,while at the same time effectively improving the physiological response to resistance exercise, increasing the maximal force production of muscles in both men and women.

The Mayo Clinic states that creatine has been associated with asthmatic symptoms and warns against consumption by persons with known allergies. Creatine cannot be recommended during pregnancy or breastfeeding due to a lack of scientific information. Pasteurized cow’s milk contains higher levels of creatine than human milk.

Medium Chain Triglycerides– (MCTs) are medium-chain (6 to 12 carbons) fatty acid esters of glycerol. Some studies have shown that MCTs can help in the process of excess calorie burning, and thus weight loss. MCTs are also seen as promoting fat oxidation and reduced food intake. There has also been interest in MCTs from endurance athletes and the bodybuilding community. While there seem to be health benefits from MCTs, a link to improved exercise performance is weak.

Medium-chain triglycerides are generally considered a good biologically inert source of energy that the human body finds reasonably easy to metabolize. They have potentially beneficial attributes in protein metabolism but may be contraindicated in some situations due to their tendency to induce ketogenesis and metabolic acidosis. Their use is not recommended for diabetics unless under supervised medical treatment and those with liver problems due to the added stress they may put on the organ.

Bioperine® (Piper nigrum) –  BioPerine ® Is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). Black Pepper Nature’s Bioavailability Enhancing Thermonutrient. Helps the body absorb  nutrients.

Extract of grape seed (Vitis vinifera)

Grape seed oil (also called grapeseed oil or grape oil) is technically a fruit oil, even though it is commonly referred to as a vegetable oil. It is pressed from the seeds of various varieties of Vitis vinifera grapes, an abundant by-product of winemaking. Potential medicinal benefits:  grape seeds contain antioxidants and other biologically active compounds,  A 1993 study supports the claim that grape seed oil increases high-density lipoprotein (HDL-C or “good cholesterol”) levels and reduces LDL levels.

alpha lipoic acid (ALA)

Lipoic acid (LA), also known as α-lipoic acid and alpha lipoic acid(ALA)  is an organosulfur compound derived from octanoic acid. LA contains two vicinal sulfur atoms (at C6 and C8) attached by a disulfide bond and is thus considered to be oxidized (although either sulfur atom can exist in higher oxidation states). 

Beneficial effects from  numerous research studies and clinical trials: Prevent organ dysfunction-Reduce endothelial dysfunction and improve albuminuria-Treat or prevent cardiovascular disease-Accelerate chronic wound healing-Reduce levels of ADMA in diabetic end-stage renal disease patients on hemodialysis-Management of burning mouth syndrome-Reduce iron overload-Treat metabolic syndrome-Improve or prevent age-related cognitive dysfunction-Prevent or slow the progression of Alzheimer’s Disease-Prevent erectile dysfunction (animal models but anecdotally applies to humans as well)-Prevent migraines-Treat multiple sclerosis-Treat chronic diseases associated with oxidative stress-Reduce inflammation-Inhibit advanced glycation end products (AGE)-Treat peripheral artery disease.

Clinical trials and approved uses

RLA is being used in a federally funded clinical trial for multiple sclerosis at Oregon Health and Science University.   R-lipoic acid (RLA) is currently being used in two federally funded clinical trials at Oregon State University to test its effects in preventing heart disease and atherosclerosis.   Alpha-lipoic acid is approved in Germany as a drug for the treatment of polyneuropathies, such as diabetic and alcoholic polyneuropathies, and liver disease. Berkson BM. “A Conservative Triple Antioxidant Approach to the Treatment of Hepatitis C. Combination of Alpha-Lipoic Acid (Thioctic Acid), Silymarin and Selenium. Three Case Histories.” Medizinische Klinik 94(3), 1999: 84-89; Bartter FC, Berkson BM, Gallelli J and Hiranaka P. “Treatment of Four Delayed-Mushroom-Poisoning Patients with Thioctic Acid.” in Amanita Toxins and Poisonings, eds Faulstich, H., Kommerell, B., and T.Wieland, Verlag Gerhard Witzstrock, Baden-Baden, New York 1980. Berkson, BM. “Thioctic Acid in the Treatment of Poisoning with Alpha amanitin (acute hepatic necrosis).” Aminita Toxins and Poisonings, 1980. Amanita Toxins and Poisonings, 203 (Heidelberg: International Amanita Symposium, Nov. 1-3, 1978). eds Faulstich, H., Kommerell, B., and Th. Wieland, Verlag Gerhard Witzstrock, Baden-Baden, Koln, New York 1980.Berkson, B. 1979. Thioctic acid in treatment of hepatotoxic mushroom poisoning . New England Journal of Medicine. 300:371.

Coenzyme Q 10:

Heart health: Coenzyme Q10 helps to maintain a healthy cardiovascular system.
 Migraine headaches:Supplementation of coenzyme Q10 has been found to have a beneficial effect on the condition of some sufferers of migraine headaches.
Cancer:CoQ10 is also being investigated as a treatment for cancer, and as relief from cancer treatment side-effects.
Cardiac arrest:Another recent study shows a survival benefit after cardiac arrest if coenzyme Q10 is administered in addition to commencing active cooling of the body to 90–93 degrees Fahrenheit (32–34 degrees Celsius).
Blood pressure:There are several reports concerning the effect of CoQ10 on blood pressure in human studies
Periodontal disease:Studies have shown that diseased gum tissue is deficient in CoQ10 compared to healthy gum tissue
Lifespan:One study demonstrated that low dosages of coenzyme Q10 reduce oxidation and DNA double-strand breaks, and a combination of a diet rich in polyunsaturated fatty acids and coenzyme Q10 supplementation leads to a longer lifespan in rats.

Radiation injury: In 2002, a study reported that, in rat experiments, coenzyme Q10 taken as dietary supplement reduced radiation damage to the animals’ blood.

Parkinson’s disease: A 2002 study in 80 Parkinson’s disease patients found 1200 mg/day reduced the progression by 44%.[70][71] A phase III trial of 1200 mg/d and 2400 mg/d ran until August 2011. This study was terminated and the summary concluded: “The investigational drug is unlikely to demonstrate efficacy over placebo for this indication. However, no safety issues were discovered

Meat and fish are the richest source of dietary CoQ10 and levels over 50 mg/kg can be found in beef, pork and chicken heart, and chicken liver. Dairy products are much poorer sources of CoQ10 compared to animal tissues. Vegetable oils are also quite rich in CoQ10. Within vegetables, parsley, and perilla are the richest CoQ10 sources, but significant differences in their CoQ10 levels can be found in the literature. Broccoli, grape, and cauliflower are modest sources of CoQ10. Most fruit and berries represent a poor to very poor source of CoQ10, with the exception of avocado, with a relatively high CoQ10 content. According to the Mayo Clinic, “CoQ10 has been used, recommended, or studied for numerous conditions, but remains controversial as a treatment in many areas.”  Coenzyme Q-10, in its reduced form as solubilized ubiquinol, is approved for use as an orphan product in the treatment of Huntington’s disease and pediatric congestive heart failure; other uses are still unproven, including in the treatment of high triglycerides levels and athletic performance.

L-Carnitine

Carnitine is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.    In living cells, it is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy. It is widely available as a nutritional supplement. Carnitine was originally found as a growth factor for mealworms and labeled vitamin Bt. Carnitine exists in two stereoisomers: Its biologically active form is L-carnitine, whereas its enantiomer, D-carnitine, is biologically inactive.

Effects on bone mass: In the course of human aging, carnitine concentration in cells diminishes, affecting fatty acid metabolism in various tissues. Particularly adversely affected are bones, which require continuous reconstructive and metabolic functions of osteoblasts for maintenance of bone mass.

Antioxidant effects:The carnitines exert a substantial antioxidant action, thereby providing a protective effect against lipid peroxidation of phospholipid membranes and against oxidative stress induced at the myocardial and endothelial cell level,

Heart conditions:Carnitine is primarily used for heart-related conditions. Several clinical trials show that L-carnitine and propionyl-L-carnitine can be used along with conventional treatment for angina to reduce medication needs and improve the ability of those with angina to exercise without chest pain.There is little evidence about a positive effect of the use of carnitine after a heart attack. Some studies suggest people taking L-carnitine may be less likely to suffer a subsequent heart attack or experience chest pain and abnormal heart rhythms. However, other studies have not found similar benefits.Further research on this subject is needed.

Kidney disease and dialysis: Because kidneys produce carnitine, kidney disease may lead to the deficiency of carnitine in the body. Thus, carnitine may be prescribed to those with kidney disease.

Effect in male infertility:   The use of carnitine showed some promise in a controlled trial in selected cases of male infertility by improving sperm quality. L-Carnitine supplementation has also shown to have beneficial effects in the treatment of varicocele, a major cause of male infertility.

As a weight loss supplement:

“Although L-carnitine has been marketed as a weight-loss supplement, there is no scientific evidence to show that it improves weight loss; however, some studies show that oral carnitine reduces fat mass, increases muscle mass, and reduces fatigue. All of these effects may contribute to weight loss.” Furthermore, whereas researchers in the 20th century failed to show that muscle carnitine content could be increased by dietary supplementation, this may have been in part due to inadequate lengths of the supplementation periods.In 2011, researchers using L-carnitine L-tartrate supplementation for six months in a well-controlled study demonstrated not only increased muscle carnitine in subjects without carnitine deficiencies, but also an impact on muscle metabolism and performance; however, measurements of lipid oxidation were not taken in this study, and further research is needed.

Regular supplements of L-carnitine, however, contribute to energy metabolism and improved neurotransmitter function in the brain in elderly patients.

As an antidote in valproic acid poisoning “[In the treatment of valproate toxicity] L-carnitine supplementation …is thought to provide benefit, particularly in patients with concomitant hyperammonemia, encephalopathy, and/or hepatotoxicity.”Further trials are warranted, as benefit is largely theoretical, rather than proven at this stage.

To improve symptoms in moderate asthmatics L-carnitine levels are lower in moderate persistent asthmatic children as compared to healthy control children. Asthmatic children who received L-carnitine supplementation for six months showed statistically significant improvement in their ‘asthma control testing’ and in their pulmonary function tests.

To improve fatigue resulting from ifosfamide cancer chemotherapy High doses of the chemotherapy agent ifosfamide, due to its potential nephrotoxicity, may cause urinary loss of carnitine. One study suggests, as it is essential for energy production by mitochondria, L-carnitine may have a role in reducing ifosfamide-associated fatigue.

In conclusion

We find Tonalin(conjugated linoleic acid{CLA}) to be safe, scientifically proven, effective nutritional supplement that contains no stimulants of any kind.  those that are greatly overweight should take caution when using. Phosphatidylserine may reduce the risk of dementia; PS supplementation promotes a desirable hormonal balance for athletes. PS is Generally Recognized As Safe

Phosphatidylcholine has been known to slow down aging-related processes, and improve brain functioning . Though a study has linked the microbial catabolites of phosphatidylcholine with increased atherosclerosis through the production of choline, trimethylamine oxide, and betaine. However, the validity of this study is disputed because the form of choline used was contaminated with trimethylamine oxide (TMAO). A 1999 study by other authors who studied 46 different foods did not find choline-rich foods to cause TMAO

 Research has shown  Creatine Monohydrate supplementation at a rate of 5 to 20 grams per day appears to be very safe and largely devoid of adverse side-effects,while at the same time effectively improving the physiological response to resistance exercise, increasing the maximal force production of muscles in both men and women. Though the Mayo Clinic states that creatine has been associated with asthmatic symptoms and warns against consumption by persons with known allergies. Creatine cannot be recommended during pregnancy or breastfeeding due to a lack of scientific information. Pasteurized cow’s milk contains higher levels of creatine than human milk.

Medium Chain Triglycerides  can help in the process of excess calorie burning, and thus weight loss, and are also seen as promoting fat oxidation and reduced food intake. Their use is not recommended for diabetics unless under supervised medical treatment and those with liver problems due to the added stress they may put on the organ.

Bioperine® (Piper nigrum) which is Black pepper or long pepper, helps the body absorb  nutrients.

Extract of grape seed (Vitis vinifera) grape seeds contain antioxidants and other biologically active compounds, A 1993 study supports the claim that grape seed oil increases high-density lipoprotein (HDL-C or “good cholesterol”) levels and reduces LDL levels.

Alpha-Lipoic Acid is  considered to be oxidized . Research in many areas show positive results.

Coenzyme Q 10  study demonstrated that low dosages of coenzyme Q10 reduce oxidation and DNA double-strand breaks, and a combination of a diet rich in polyunsaturated fatty acids and coenzyme Q10supplementation leads to a longer lifespan in rats.  Even so according to the Mayo Clinic, “CoQ10 has been used, recommended, or studied for numerous conditions, but remains controversial as a treatment in many areas.”  Coenzyme Q-10, in its reduced form as solubilized  ubiquinol, is approved for use as an orphan product in the treatment of Huntington’s disease and pediatric congestive heart failure;  other uses are still unproven, including in the treatment of high triglycerides levels and athletic performance.

 L-Carnitinecarnitine reduces fat mass, increases muscle mass, and reduces fatigue. Regular supplements of L-carnitine, however, contribute to energy metabolism and improved neurotransmitter function in the brain in elderly patients.

 

 

 

A Pretty good Product that Pro Vantage

Order yours today at  cinjoco@hotmail.com

Get my Pro Vantage     email me today cinjoco@hotmail.com

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

http://en.wikipedia.org/wiki/Carnitine#Physiological_effects
 http://en.wikipedia.org/wiki/Coenzyme_Q10#CoQ10_deficiency_and_toxicity
http://en.wikipedia.org/wiki/Alpha-lipoic_acid#Possible_beneficial_effects

http://en.wikipedia.org/wiki/Alpha-lipoic_acid#Possible_beneficial_effects

http://en.wikipedia.org/wiki/Grape_seed_oil

http://en.wikipedia.org/wiki/Creatine_monohydrate

http://en.wikipedia.org/wiki/Phosphatidylserine

http://en.wikipedia.org/wiki/Conjugated_linoleic_acid

www.wellnesspartners.com/tonalin

What is in Reliv?

What is in Reliv ? Inside this blog are some of the ingredients on the side of the Reliv Now. What is in Reliv are many nutrients to feed our bodies the food it needs to work, heal, play and just be.

What is in Reliv ? Inside this blog are some of the ingredients on the side of the Reliv Now. A discussion of the benefits of the ingredients of Reliv Now. Including LunaRich(lunasin) and its health promoting characteristics ,ChromeMate and how it betters the users overall health, OptiZinc® how it helps cell function, n-zimes how they improve digestion and a decrease of indigestion.Isolase designed to increase the absorption of isoflavones. Finally  pycnogenol benefits: ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES ,ANTI-OXIDATIVE ACTIVITIES, SYSTEMIC LUPUS ERYTHEMATOSUS  ,ASTHMA ,CANCER / TUMOR ,VENOUS THROMBOSIS, THROMBOPHLEBITIS, PLATELET AGGREGATION,RETINOPATHY,CHOLESTEROL DIABETES,ERECTILE DYSFUNCTION, SPERM QUALITY AND FUNCTION. ,AGING,ALZHEIMER’S DISEASE,WOUND HEALING AND SCAR FORMATION,DYSMENORRHEA.

Lunasin?(LunaRich in Reliv Now and SoySentials)
Lunasin is a soy peptide that exhibits health promoting characteristics. Scientific evidence indicates that Lunasin is a key component in soy protein responsible for its cholesterol-lowering properties. Lunasin is a unique, 43 chain amino acid peptide found within soybeans. Recent research and development surrounding this soy peptide focuses on promotion of healthy cholesterol levels. In addition to lunasin exhibiting cholesterol lowering properties, research shows it also has cancer preventive properties.

Partnerships & Resources
http://www.lunasin.com/Partnerships.aspx

ChromeMate

ChromeMate aims to minimize food cravings, reduce cholesterol levels, suppress appetite, and better the user’s overall health. ChromeMate is directed to be taken three times each day, prior to each meal. The primary active component found in this supplement is Chromium, which is bonded with Polynicotinate (niacin). The purpose of this substance is to regulate the user’s insulin levels in order to burn off carbohydrates, fats, and proteins more efficiently as fuel. Studies have show that the component Chromium offers “16 different trace minerals” that the human body requires for daily health maintenance. Other than aid with fat reduction, ChromeMate tablets may increase the user’s energy levels.

http://www.dietspotlight.com/chromemate-review/

OptiZinc®

OptiZinc® and higher potency L-OptiZinc® are unique forms of methionine-bound zinc, an essential trace mineral required for numerous vital cell functions, including growth and development, reproduction, digestion, and for proper brain, nerve, vision and immune function. OptiZinc and L-OptiZinc supply antioxidant benefits.*
Zinc is an essential trace mineral involved in numerous enzyme systems the body needs to keep healthy and fit. OptiZinc® and L-OptiZinc® are 1:1 complexes of zinc and methionine, the amino acid best absorbed by the body. Preclinical studies show that OptiZinc and L-OptiZinc are absorbed better, retained longer and are more effective than other zinc supplements tested.*

http://www.interhealthusa.com/Ingredients/L-OptiZinc.aspx
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to cure, mitigate, treat or prevent any disease.

n-zimes

The human body naturally produces proteins called enzymes to carry out a number of functions. The benefits of enzymes, including improved digestion and a decrease of indigestion, better nutrient absorption and elevated immune function. These plant source-based enzyme contain four types of enzymes needed to break down the four basic food components, including protein (protease), carbohydrates (amylase), fats (lipase) and fiber (cellulase). If you’re looking for getting the most out of your food and decreasing the symptoms of indigestion, try N·Zimes today. Start feeling better, the natural way!
http://www.enzymesinc.com/index.php?id=58

Isolase

A unique enzyme composition designed to increase the absorption of isoflavones.
http://www.nationalenzyme.com/NEC-products.html

pycnogenol benefits

ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES
scientists found that pycnogenol had anti-inflammatory and immunosuppressive activities

ANTI-OXIDATIVE ACTIVITIES
Pycnogenol was found to have strong free radical-scavenging activities against reactive oxygen and nitrogen species.

SYSTEMIC LUPUS ERYTHEMATOSUS
Pycnogenol treatment reduced the reactive oxygen species production, apoptosis, p56(lck) specific activity and erythrocyte sedimentation rate and improved SLE disease activity index in systemic lupus erythematosus (SLS). [7]

ASTHMA
Because of pycnogenol’s anti-oxidant and anti-inflammatory activities, it may have benefits on asthma.

CANCER / TUMOR
pycnogenol selectively induced death in human mammary cancer cells (MCF-7) and not in normal human mammary MCF-10 cells.

VENOUS THROMBOSIS, THROMBOPHLEBITIS, PLATELET AGGREGATION
In a study, pycnogenol inhibited NF-kappa B activation, VCAM-1 and ICAM-1 expression. Thus, pycnogenol might play an important role in halting or preventing the atherogenic process. [13]

RETINOPATHY
With pycnogenol-treatment, the retinal function stopped to deteriorate and visual acuity significantly recovered.

ALZHEIMER’S DISEASE
data suggest that pycnogenol may be useful for the prevention and/or treatment of vascular or neurodegenerative diseases associated with Abeta toxicity. [20

ON CHOLESTEROL PROFILE
Devaraj S et al, University of California, Davis, tested the effect of Pycnogenol supplementation on measures of oxidative stress and the lipid profile in humans. And, they found that a significant increase in oxygen radical absorbance capacity (ORAC) in plasma throughout the supplementation period and the ORAC value returned to baseline after the 4-wk washout period. They also found that Pycnogenol significantly reduced LDL-cholesterol levels and increased HDL-cholesterol levels in plasma of two-thirds of the subjects. [22].

DIABETES
Liu X et al, Guang An Men Hospital of Chinese Medical Science Research Institute, Beijing, PR China conducted a double-blind, placebo-controlled, randomized, multi-center study was performed with 77 diabetes type II patients to investigate anti-diabetic effects of the French maritime pine bark extract, Pynogenol. They found that supplementation with dosage of 100 mg Pycnogenol for 12 weeks, during which a standard anti-diabetic treatment was continued, significantly lowered plasma glucose levels as compared to placebo. And, it also improved endothelial function. [28]

ERECTILE DYSFUNCTION
They orally administered 40 men, aged 25-45 years, with pycnogenol and L-arginine. They found that treatment with a combination of L-arginine and Pycnogenol for the following month increased the number of men with restored sexual ability to 80%. And, 92.5% of the men experienced a normal erection, after the third month of treatment. They concluded that oral administration of L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with ED. [29]

SPERM QUALITY AND FUNCTION
Roseff SJ, West Essex Center for Advanced Reproductive Endocrinology, NJ, found that the mean sperm morphology following Ham’s F-10 capacitation increased by 38% following a pycnogenol treatment (dosage 200 mg daily for 90 days) to 19 subfertile men, and the mannose receptor binding assay scores improved by 19%. [30]

WOUND HEALING AND SCAR FORMATION
Blazso G et al, University of Szeged, Hungary, applied pycnogenol to experimental wounds inflicted on healthy rats by means of a branding iron. They found that 1% Pycnogenol significantly shortened the wound healing time as well as the diameter of the scars. And, the wound healing time was found to be dose-dependent. [31]

DYSMENORRHEA
Kohama T et al, Keiju Medical Center, Japan, treated 47 patients with menstrual pain, aged 21-45 years, with Pycnogenol at dosage of 30 mg (2 capsules) orally twice a dysmenorrl day. The administration of Pycnogenol began on the eighth day of the first menstrual cycle and continued until the seventh day of the third menstrual cycle. They found that treatment with Pycnogenol lowered the pain scores for abdominal pain significantly (p < 0.05) as compared to pretreatment values and continuation of treatment during the second cycle produced significant pain relief (p < 0.01). [32]

AGING
Buz’Zard AR et al, Loma Linda University, CA, established an in vitro model using genetically-engineered keratinocytes to screen natural compounds for the ability to stimulate HGH secretion. They found that a combination of equal amounts of L-arginine and L-lysine, aged garlic extract (Kyolic), S-allyl cysteine and Pycnogenol significantly increased secretion of HGH in this in vitro model. [33]

http://www.zhion.com/herb/Pycnogenol_Benefits_Side_Effects.html

PYCNOGENOL SIDE EFFECTS
Probably, pycnogenol is safe with limited or no side effect. Studies reported no side effects of pycnogenol include [1] using pycnogenol for 40 men suffered from erectile dysfunction for 3 months [34] [2] using pycnogenol for patients suffered from chronic venous insufficiency. [35] [3] using pycnogenol for 30 women suffered from melasma. [37]

In a study of using pycnogenol for patients with diabetic retinopathy, the side effect was found to be mild and it was confined to gastric discomfort. [36] While in another study of 58 patients suffered from hypertension (hight blood pressure), the side effects included gastrointestinal problems, vertigo, headache and nausea. [39]

Pcynogenol Reviews –  Pycnogenol is an extract from the bark of French Maritime Pine trees that grow in the Landes Forest of southwestern France. Pycnogenol contains concentrated levels of unique flavonoid compounds.

Reference to Pycngenol [1] Cho KJ et al,Toxicol Appl Pharmacol. 2000 Oct 1;168(1):64-71 [2] Packer L et alFree Radic Biol Med. 1999 Sep;27(5-6):704-24 [3] Nelson AB et al, Loma Linda University, Drug Dev Ind Pharm. 1998 Feb;24(2):139-44] [4] Zhang D et al Academia Sinica, Beijing, Toxicol Ind Health. 2002 Jun;18(5):215-24] [5] Ni Z et al, China,Phytother Res. 2002 Sep;16(6):567-71.] 6] Kimbrough C et al, Loma Linda University, CA, Phytomedicine. 2002 Jul;9(5):410-3][7] Stefanescu M et al, Cantacuzino Institute, Romania, found thatPhytother Res. 2001 Dec;15(8):698-704. [8] Hosseini S et al, The University of Arizona, AZJ Med Food. 2001 Winter;4(4):201-209]. [9] Lau BH et al, Loma Linda University, CAJ Asthma. 2004;41(8):825-32. [10] Sime S and Reeve VE., University of Sydney, Australia, Photochem Photobiol. 2004 Feb;79(2):193-8. [[11] Huynh HT and Teel RW, Loma Linda University, CAAnticancer Res. 2000 Jul-Aug;20(4):2417-20 [12] Feng WH et al, Beijing, Phytomedicine. 2002 Jul;9(5):414-8] [13] Peng Q et al, Loma Linda University, California,Cell Mol Life Sci. 2000 May;57(5):834-41 [14] Belcaro G et al, L’Aquila University, Italy, Clin Appl Thromb Hemost. 2004 Oct;10(4):373-7] [15] Koch R, Wolfsschlucht 6a, 34117 Kassel, Germany , Phytother Res. 2002 Mar;16 Suppl 1:S1-5. [15] Petrassi C et al, Universita degli Studi di L’Aquila, Italy, Phytomedicine. 2000 Oct;7(5):383-8. [16] Putter M et al, Westfalische Wilhelms-Universitat Munster, Germany Thromb Res. 1999 Aug 15;95(4):155-61 [17] [Araghi-Niknam et al, University of Arizona, AZ, Integr. Med.. 2000 Mar 21;2(2):73-77].[19] Phytother Res. 2001 May;15(3):219-23].[18] [Int Ophthalmol. 2001;24(3):161-71] [[20] [Brain Res Mol Brain Res. 2002 Jul 15;104(1):55-65] [21] Biol Pharm Bull. 2000 Jun;23(6):735-7][21] Free Radic Res. 2000 Feb;32(2):115-24] [22] Lipids. 2002 Oct;37(10):931-4] [23] Phytother Res. 2002 Mar;16 Suppl 1:S1-5][24] Phytother Res. 2000 Sep;14(6):472-3][25] Devaraj S et al, University of California, Davis,Lipids. 2002 Oct;37(10):931-4] [26] Maritim A et al, J Biochem Mol Toxicol. 2003;17(3):193-9][27] [J Biochem Mol Toxicol. 2003;17(3):193-9, Details in Section of Antioxidant Activity].[28]Life Sci. 2004 Oct 8;75(21):2505-13] [29] J Sex Marital Ther. 2003 May-Jun;29(3):207-13][30] [J Reprod Med. 2002 Oct;47(10):821-4][31] [Phytother Res. 2004 Jul;18(7):579-81][32] J Reprod Med. 2004 Oct;49(10):828-32] [33] [Growth Horm IGF Res. 2002 Feb;12(1):34-40] [34][Treatment of erectile dysfunction with pycnogenol and L-arginine, J Sex Marital Ther. 2003 May-Jun;29(3):207-13]. [35] [Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000 oct;7(5):383-8.][36] [Pycnogenol for diabetic retinopathy. A review. Int Ophthalmol. 001;24(3):161-71] [37] [Phytother Res. 2002 Sep; 16(6):567-71.][39] Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2; 74(7):855-62].

Want to learn more about Reliv and what it can do for you? Send me an email cinjoco@hot mail.com …Reliv Now is full of vital nutrients that our bodies need on a daily basis. What is in Reliv? A lot of good things to help your body, mind and spirit.

Super Soy

Nutrition Science has regarded soy as a super food for many years now. According to the FDA “25 grams of soy protein per day, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease,” Science continues to uncover reason to consider soy a super food, like the recent discovery of the ” nutritional magic” behind soy’s heart health benefits: a soy peptide called lunasin.

Lunasin is a naturally occuring peptide, it disrupts production of cholesterol in the liver and clears LDL from bloodstream.
“A growing body of research shows that the lunasin peptide is one of the most important bioactive components of soy,” said Dr. Alfredo Galvez, who first discovered lunasin while studying soy in 1996. He explains, “Among other benefits, lunasin demonstrates superior support for cardiovascular health and exhibits significant anti-inflammatory properties.”

Over 80% of cholesterol comes from the liver, so the most effective way to lower LDL (bad) cholesterol is to control the liver’s internal production. The lunasin peptide does so in two ways:
1. selectively disrupts a step in the production of an enzyme key to cholesterol synthesis in the liver.
2. increases the number of receptors available in liver cells to clear LDL cholesterol from the bloodstream.

“The soy peptide, lunasin, can actually work better than statin drugs to improve cholesterol,” said Dr. Galvez. “This is because lunasin works at an earlier stage in the body’s internal cholesterol production process. Lunasin reduces the production of the cholesterol synthesis enzyme, whereas statins block the enzyme after it has already been produced. Blocking too much of the enzyme can lead to serious side effects.”

Soy Much Better!
Soy has come a long way since tofu first entered the mainstream decades ago. Today, a breakthrough soy powder from Reliv International is revolutionizing the soy supplement world. Reliv worked with SoyLabs, LLC to develop LunaRichTM — the first soy powder on the market to fully harness the power of lunasin.
LunaRich contains five to ten times more lunasin than ordinary soy powders. Reliv has announced that it has incorporated LunaRich into its cutting-edge essential nutrition product, Reliv Now®.
“Reliv Now has always provided optimal amounts of vitamins, minerals, antioxidants and soy protein. By adding LunaRich, we’ve taken the product to a new level of effectiveness,” said Dr. Carl Hastings, Reliv’s chief scientific officer “It’s very exciting to be the first and only company to offer this extraordinary nutritional breakthrough.”
“With LunaRich, Reliv is leading the way in bringing lunasin to the consumer market. LunaRich is unlike any soy powder available anywhere else,” said Ryan Schmidt, SoyLabs’ chief executive officer.
What does all of this mean to you? It means nutrition scientists had it right about soy all along. So, fall in love with soy all over again. Your heart will love you for it!